Recombinant human IgG1 based Fc multimers, with limited FcR binding capacity, can effectively inhibit complement-mediated disease —Download pdf
Haoping Sun, PhD, Henrik S. Olsen, PhD, Emmanuel Y. Mérigeon, MS, Edward So, MS, Erin Burch, MS, Susan Kinsey, BA, John C. Papadimitriou, MD PhD, Cinthia B. Drachenberg, MD, Søren M. Bentzen, PhD, David S. Block, MD, Scott E. Strome, MD, Xiaoyu Zhang, PhD. Journal of Autoimmunity. 2017 Aug;1-12.

A fully recombinant human IgG1 Fc multimer (GL-2045) inhibits complement-mediated cytotoxicity and induces iC3b. —Download pdf
Zhou H, Olsen H, So E, Mérigeon E, Rybin D, Owens J, LaRosa G, Block DS, Strome SE, and Zhang X. Blood Advances. 2017 Mar; 1(8):504-515.

Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease. —Download pdf
Zhang X, Olsen HS, Chen S, So E, Zhou H, Burch E, Mérigeon EY, Block DS, Strome SE. J Immunol. 2016 Feb 1;196(3):1165-76.

A phase I dose escalation trial of MAGE-A3- and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). —Download pdf
Zandberg DP, Rollins S, Goloubeva O, Morales RE, Tan M, Taylor R, Wolf JS, Schumaker LM, Cullen KJ, Zimrin A, Ord R, Lubek JE, Suntharalingam M, Papadimitriou JC, Mann D,Strome SE, Edelman MJ. Cancer Immunol Immunother. 2015 Mar;64(3):367-79.

Fc fusion as a platform technology: potential for modulating immunogenicity —Download pdf
Ditza Levin, Basil Golding, Scott E. Strome, and Zuben E. Sauna. CellPress – Trends in Biotechnology 2014 :1-8.

Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells —Download pdf
Aaron P. Rapoport, Nicole A. Aqui, Edward A. Stadtmauer, et al. Clin Cancer Res. 2014; 20:1355-1365.

Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis —Download pdf
Muthusamy Thiruppathia, Jian Rong Shenga, Liangcheng Lia, Bellur S. Prabhakara, Matthew N. Meriggioli. Journal of Autoimmunity. January 2014; 1-10.

Beneficial effect of a multimerized immunoglobulin Fc in an animal model of inflammatory neuropathy (experimental autoimmune neuritis) —Download pdf
Marzieh Niknami, Min-Xia Wang, Toan Nguyen, John D. Pollard. Journal of the Peripheral Nervous System. 2013; 18:141–152.

Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer —Download pdf
Ajay Jain, Bhawna Poonia, Edward C. So, Ravi Vyzasatya, Erin E. Burch, Henrik S. Olsen, Emmanuel Y. Mérigeon, David S. Block, Xiaoyu Zhang, Dan H. Schulze, Nader N. Hanna, William S. Twadell, Harris G. Yfantis, Siaw L. Chan, Ling Cai, Scott E. Strome.  European Journal of Cancer 2013; 49:3344-3352.

Induction of MAGE-A3 and HPV-16 immunity by Trojan vaccines in patients with head and neck carcinoma —Download pdf
Caroline J. Voskens, Duane Sewell, Scott E. Strome. Head Neck. December 2012; 34(12): 1734-1746.

Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice —Download pdf
Ajay Jain, Henrik S. Olsen, Ravi Vyzasatya, Erin Burch, Yukimi Sakoda, Emmanuel Y. Mérigeon, Ling Cai, Changwan Lu, Ming Tan, Koji Tamada, Dan Schulze, David S. Block, Scott E. Strome. Arthritis Research & Therapy. 2012; 14:R192.